Day 126 of 150 Memory Difficulty 5/10

Declarative memory rides on a four-region medial temporal network

Quick answer

Declarative memory rides on a four-region medial temporal network. Today's question (Medial temporal lobe memory system) asks about a finding from Squire, L. R., & Zola-Morgan, S. in 1991. The correct option is Hippocampus together with the entorhinal, perirhinal, and parahippocampal cortices, jointly supporting declarative memory — full explanation, primary source, and glossary cross-links below.

Today's question

Squire & Zola-Morgan (1991) characterized the medial temporal lobe (MTL) memory system as comprising:

  1. A Hippocampus alone
  2. B Hippocampus and amygdala
  3. C Hippocampus together with the entorhinal, perirhinal, and parahippocampal cortices, jointly supporting declarative memory
  4. D Cerebellum and basal ganglia
Reveal the answer and explanation

Correct: C — Hippocampus together with the entorhinal, perirhinal, and parahippocampal cortices, jointly supporting declarative memory

Drawing on lesion data from monkeys and amnesic patients, Squire & Zola-Morgan (1991) defined the medial temporal lobe (MTL) memory system as a set of densely interconnected structures — hippocampus plus the entorhinal, perirhinal, and parahippocampal cortices — that jointly support declarative memory for facts and events. Damage to any component impairs new declarative learning, while procedural and skill memory remain spared. The framework reconciled the patient HM literature, monkey-lesion findings, and earlier hippocampus-only views, and remains the canonical anatomical account of conscious-recall memory in humans and other mammals.

About the source

Squire, L. R., & Zola-Morgan, S. (1991). The medial temporal lobe memory system. Science, 253(5026), 1380–1386.

Every Cognition Bible question cites a primary source — a paper, book chapter, or monograph that exists, that we can point to on Google Scholar, and whose finding the question accurately summarizes. No fabricated authority strings, no name-drops without paper-level grounding.

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